Reasons why the performance of POCT is often considered not as reliable as central laboratory testing • Possible performance issues with some forms of POCT technology and its fitness for purpose • Problems with direct comparison of POCT and central laboratory results • Possible reasons for discrepancies between POCT and central laboratory results • Skill requirements for POCT personnel • Sample quality and POCT performance • Performance assessment, quality control and proficiency testing issues for POCT • Measurement uncertainty for POCT and central laboratory results, and the impact on result interpretation • Procedures by which improved performance of POCT can be achieved
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